Do Antidepressants Interact With Modafinil or Other Modafinil Analogues?

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Do Antidepressants Interact With Modafinil or Other Modafinil Analogues?

The following blog post is one that I have been looking forward to writing about for some time now, as it highlights a common issue in the Nootropics community that I have been reading about on forums for over a year. This would be the topic of whether or not Antidepressants interact with Modafinil, Adrafinil and other Modafinil analogues, and of whether or not they interact poorly with antidepressants. I had long read about individuals taking about antidepressants such as Paxil and Zoloft having an adverse reaction with drugs like Adderall and Ritalin, powerful prescription amphetamines, but had never thought that they could also have something of an adverse drug reaction among Modafinil, Armodafinil, Artvigil, Provigil, Nuvigil and other related prescription drugs in the Modafinil category. The following blog post will confirm my suspicions and will provide some hefty research as to why if you are taking antidepressants, you may want to at least take a day off of them on days you want to take Modafinil, or at the very least take the lowest dosage that you possibly can for each drug.

Additional research on the subject of using Modafinil with antidepressants is as follows:

Anyone here taking Modafinil with any SSRI’s (Depression & Anxiety Meds)? from afinil

The gist of the research from this says that using Modafinil atop antidepressants can lead to some pretty nasty side effects, more information on this later in the article.

How Antidepressants Interact With Modafinil

Studies suggest that due to Modafinil’s fairly mild effects in comparison to Adderall, Ritalin and other notable prescription ADHD amphetamines, that using it on top of antidepressants is not likely to cause serotonin syndrome. With this in mind however, just for the sake of caution, mixing these two drugs in conjunction with one another is not something that I would necessarily recommend, and in fact I would say that if you Modafinil and Antidepressant Interactionsare a regular user of antidepressants and you want to stack Modafinil on top of your medication, to instead only take Modafinil on days that you do not also take your antidepressant prescription. Whether it be Paxil, Zoloft or any other name brand SSRI medication that bumps up serotonin levels to a significant degree, the general rule is that mixing it with stimulants, including Modafinil, is not necessarily a good idea.

How Antidepressants Interact With Adrafinil

With Adrafinil, the pro drug of Modafinil, a drug that quite literally converts itself to Modafinil in the human liver and therefore is essentially the same chemical make up just slightly weaker and dirtier, would also have negative effects if it were to be mixed with antidepressants. Going back to what I said above with regards to taking SSRI medications on your off days from Modafinil, this is the bare MINIMUM of how you should limit yourself if you are taking both of these medications. The correct medical rule of thumb, which you will find if you are to read any of the above .gov research clinical trial links, or magazine reviews on this subject within the article, is to wait until the SSRI is entirely out of your system in order to 100% block the risk of any excess side effects.

How Long Does Modafinil Last?

Modafinil is typically going to last around 8 to 12 hours, and aside from this can have a lingering after effect that lasts around 2 to 3 hours once the majority of the effects from the Modafinil have worn off. This is something to absolutely keep in mind if you are also someone that takes anti-depressants and also keep in mind that Modafinil generally has a half life of around 15 hours, and that the rule of thumb with any drug, prescription or otherwise, is that it takes around five half lives in order to get the drug fully out of your system, use this information to proceed with caution if you are someone that is taking both Modafinil and antidepressants, or both ADHD medications and anti-depressants.

What Other Types of Drugs are Bad to Mix With Antidepressants, Can You Take Adderall With Antidepressants?

No, you actually cannot take Adderall with antidepressants either, and also cannot take Adderall with Modafinil, as it can put excess strain on the heart. My own personal experience of mixing Adderall with Modafinil is not one that I remember fondly, as it was back in my college days when I was an 18 year old, young and restless in college, still experimenting with things that I likely should not have been. I took one, 200 milligram tablet of Modafinil, and I also took 1, 30 milligram pill of Adderall..I can say of this, that it was not a good idea and that I would spend the next 15 hours having a horrible panic attack, constantly holding onto my chest after I would take a deep breath fearing that I was going to have to go to the hospital. Luckily for me it wore off after about fifteen hours and I was able to avoid any serious problems, but let me tell you, it was a very unpleasant experience. Do not mix Adderall or Ritalin with Modafinil or Adrafinil and do not mix antidepressants with either of these, instead, take them on your off days from SSRI medications, or better yet, wait until the drugs are entirely out of your system.

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Final Thoughts On Modafinil and Anti-Depressants, The Verdict Is Out! Is It Safe to Take Antidepressants With Modafinil Or Not?

All in all, Modafinil is an extremely powerful Nootropic Smart Drug and FDA approved medication for narcolepsy, and I would highly recommend it for any serious Nootropics users. For those that are using antidepressants or other similar SSRI’s, be sure to follow the guidelines in this blog post very carefully if you are to use Modafinil with these drugs, and ensure that you do it only on off days from the antidepressant medications and that you, for best practice, even ensure that the SSRI is out of your system before using Modafinil or any other related stimulants with it.



*Disclaimer: Statements found within have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Always consult a physician if you are unsure about taking a new supplement. Do not take this supplement if you are under 18, if you are pregnant, nursing, or have any cardiovascular issues. Scientific studies cited are not conclusive and have limitations, due to of their closed environment nature. Referenced studies will not necessarily determine your experience with a supplement, since there are many unaccounted variables, which fall outside the scope of the studies. All refunds must be brought to our attention within 7 days of delivery in order to be considered for reimbursement

  • B. R. Sharpe

    good to know, thanks! im taking prozac now, but my doctor might have me switch to something else next month, most likely Paxil or Zoloft. which of these would be least reactive with modafinil?

  • alybabjack

    So mixing Modafinil with antidepresents is “in general not a good idea”? Then how do I go about taking Modafinil if I’m on an antidepressant?