Modafinil as a Treatment for Depression

Modafinil for Depression

Modafinil for depression? It’s not as crazy as you think. There are good reasons to consider modafinil as a potential treatment for depression.

Psychiatrists are getting increasingly creative with their pharmacologic choices due to poor remission rates with conventional antidepressants. Modern antidepressants have more tolerable side effects than their predecessors, but may have sacrificed some efficacy in the process.

Cognitive Symptoms of Depression

My interest in modafinil for depression stems from the fact that there are few medications on the market that address the cognitive symptoms of depression.

Researchers and health professionals like to talk a lot about cognitive symptoms of schizophrenia, which fall under “negative symptoms.” But the cognitive symptoms of depression gets less attention in the biomedical literature.

Some depressed patients experience:

  • difficulty making decisions
  • memory impairment
  • mental sluggishness

There’s no question that these symptoms impair daily functioning. Finding a regimen that addresses both cognitive and emotional aspects of depression is a big challenge. Many patients in remission still experience mild cognitive impairment in spite of mood improvement.

Bupropion Normalizes Cognitive Deficits

A handful of antidepressants address the cognitive symptoms of depression. For example, bupropion (Wellbutrin) appears to normalize cognitive deficits in depressed patients.

Gualtieri and Johnson [6], in a previous paper, establish that:

depressed patients on modern antidepressants had, in spite of successful treatment, residual deficits in tests of effortful attention, executive function, and information processing speed

Therefore the authors asked whether some antidepressants might do a better job at mitigating the cognitive symptoms of depression than others.

So the authors conduct a naturalistic study of depressed patients that were treated with 7 different antidepressants. Their findings? Bupropion (Wellbutrin) succeeds in normalizing cognitive deficits in depressed patients.

What About Modafinil For Depression?

How are these data relevant to modafinil for depression?

Modafinil is a mood-brightening wakefulness enhancer that also seems to have nootropic effects in some people.

Modafinil is a good candidate for depressed patients because it improves motivation, attention, and reaction time while also elevating mood. Most conventional antidepressants actually increase apathy (particularly SSRIs) while stabilizing mood and making the lows more bearable.

SSRI-induced apathy is a well-known phenomenon. The cause is unknown, but some investigators have proposed some interesting hypotheses:

  • Barnhart et al[1] suggest that SSRI-induced apathy is caused by serotonergic effects in the frontal lobes or serotoninergic modulation of mid-brain dopamine
  • Wongpakaran et al[2] similarly point to frontal lobe dysfunction due to altered serotonin levels

The phenomenon of SSRI-induced apathy suggests that some antidepressants even contribute to the cognitive symptoms of depression despite improving mood.

Is Modafinil an Effective Antidepressant?

Most studies investigating modafinil for depression test modafinil as an augmentation agent. This means that modafinil is added on to another antidepressant to augment its effects. However, a few studies take a closer look at modafinil as monotherapy for depression.

Modafinil as Monotherapy: A Case Study

One case study[3] described a 49-year old man who was initially diagnosed with depression in 1995.

He was successfully treated with 20 mg paroxetine, which became ineffective one year later. He was switched to bupropion 150 mg with only partial response followed by relapse. In 1998 his psychiatrist switched him to citalopram 40 mg, which did not resolve his symptoms.

When the patient was admitted to a clinic at Robert Wood Johnson, he was hypersomnolent with diminished energy, impaired memory, decreased libido, and had gained 70 lbs.

He agreed to a monotherapy trial of modafinil 200 mg. The patient reported a positive response to modafinil within the first week. Serial evaluations revealed improvement in HAMD-24 scores. The patient commented:

So this is what life is about—I was in the basement for 10 months, titrated on/off medications for 4 years for depression, and now I’m finally back in the gym working out and feeling normal.

What’s interesting about this case report is that the patient also had co-morbid panic disorder, but modafinil did not precipitate panic attacks. Instead, his panic disorder/agoraphobia was resolved with modafinil treatment.

The patient’s improvement in HAMD-24 scores also reflected improvement in the cognitive features associated with depression.

Goss’ Meta-Analysis

Goss et. al conducted a meta-analysis of modafinil in unipolar and bipolar depression.

The meta-analysis drew on data from 6 randomized clinical trials that enrolled a total of over 900 patients. Modafinil significantly improved depression scores and remission rates. Modafinil also alleviated fatigue, which is not surprising given that it’s FDA-approved to treat narcolepsy and obstructive sleep-apnea associated fatigue.

Moreover, the adverse events reported by patients taking modafinil did not differ from placebo, suggesting that modafinil was well-tolerated.

Atypical Depression

Atypical depression is the flavor of depression that’s characterized by:

  • fatigue
  • hyperphagia (excess hunger and eating)
  • hypersomnolence (excess sleeping)

There are few good medications for atypical depression. Monoamine oxidase inhibitors are effective but have burdensome side effects like a potentially life-threatening hypertensive crisis.

Vaishnavi S and colleagues tested modafinil as monotherapy for atypical depression. It makes sense that modafinil would be re-purposed for this condition given its wakefulness enhancing effects.

Vaishnavi S reported that:

We found that modafinil significantly improved atypical depression symptoms during 12 weeks of open-label treatment (mean +/- SD Hamilton Depression Scale (29-item version) score changed from 34 +/- 8.2 at baseline to 9.7 +/- 9.3, P < 0.0001), and that benefits were maintained alike in both the continuation and placebo arms during the double-blind treatment phase (P = 0.92).

Can Modafinil Cause Depression?

There is little data on modafinil-induced depression. It seems at once strange that the same drug could both alleviate or induce depression depending on the context.

Genetic differences between patients and individual neurophysiology can account for these differing responses to modafinil’s effects.

I can’t cite any high-powered double-blind placebo-controlled trials. But my personal experience with modafinil and encounters with anecdotal reports suggests that modafinil can induce depressive symptoms. Modafinil can also exacerbate headaches, and there’s significant overlap between headaches and depression.

Some people become overstimulated or agitated on modafinil. Their sleep quality may erode over time if the drug lingers in their system at bed time.

I don’t know if you’ve heard of the Yerkes-Dodson law[4]. It illustrates the idea that there’s an optimal level of arousal to facilitate performance.

Too much arousal leads to anxiety which impairs performance. Too little arousal also impairs performance by suppressing attention and engagement.

Some people are naturally anxious – maybe their sympathetic nervous system is more sensitive. Maybe they had an attachment disorder as a child. The possible biological and psychological explanations for a baseline state of heightened anxiety are endless.

But if you’re already prone to anxiety, modafinil can shift you further in this direction by bolstering arousal and wakefulness. This leads to agitation, diminished cognitive performance, and a generally unpleasant state of hyperarousal. Such hyperarousal can be depressogenic (precipitate depression).

Depression and Benzodiazepines

The situation with modafinil and depression is vaguely analogous to benzodiazepines and depression.

Some patients with depression actually improve when Xanax (alprazolam) is added to their regimen [5]. Others worsen. You might expect patients with depression to worsen on Xanax because it’s a powerful central nervous system depressant. Depression is even in the name! But some depressed states (namely, mixed affective states) are characterized by:

  • despair
  • fatigue
  • racing thoughts
  • heightened irritability
  • pressured activity

You can see that there are both manic and depressive features in this list of symptoms. But experiencing such states does not necessarily imply a manic depression. Some depressions have agitation and irritability as prominent features.

It’s not hard to see that benzodiazepines could be helpful for such mixed states. Benzodiazepines swiftly reduce irritability, agitation, and racing thoughts, which can take the edge off of a depression. Taking alprazolam is like being wrapped in a warm blanket.

This benzodiazepine example is to show apparent contradictions in how people respond to drugs. Similarly, modafinil can help banish depression – and is well-suited to treat the cognitive symptoms of depression. Yet some patients may nonetheless find modafinil agitating, anxiogenic, and all around depressogenic.

Until pharmacogenomics becomes mainstream, the only way to find out how you’ll respond is to trial the drug under the care of your physician.


1: Barnhart WJ, Makela EH, Latocha MJ. SSRI-induced apathy syndrome: a clinical review. J Psychiatric Pract. 2004;10:196–199. [PubMed]

2: Wongpakaran N, van Reekum R, Wongpakaran T, Clarke D. Selective serotonin reuptake inhibitor use associates with apathy among depressed elderly: a case-controlled study. Ann Gen Psychiatry. 2007;6:7. [PMC free article] [PubMed]

3: Kaufman KR, Menza MA, Fitzsimmons A. Modafinil monotherapy in depression. Eur Psychiatry. 2002;17(3):167-9.

4: Yerkes, R. M. & Dodson, J. D. (1908). The Relation of Strength of Stimulus to Rapidity of Habit-Formation. Journal of Comparative Neurology and Psychology, 18, 459-482.

5: Dunlop BW, Davis PG. Combination treatment with benzodiazepines and SSRIs for comorbid anxiety and depression: a review. Prim Care Companion J Clin Psychiatry. 2008;10(3):222-8.

[^6]: Gualtieri CT, Johnson LG. Bupropion normalizes cognitive performance in patients with depression. MedGenMed. 2007;9(1):22.

Long-term Effects of Modafinil

Originally, chronic sufferers of sleep disorders would be the only long-term users of modafinil. Conditions such as narcolepsy can’t be cured, only managed. As with any medicine, long-term effects can appear far down the road. What are the long-term effects of Modafinil?

Studies have shown that modafinil is extremely safe for long-term use, with a 9-month study being the longest one available.

As of yet there are no published safety studies that examine patients for a year or more.

Taking into account what we definitely know, we can also make some projections about modafinil’s long-term effects.

Long-term effects: What we know

The first question researchers ask is “Is this drug going to be effective in the long term?” This is a huge question to answer. If a patient develops tolerance or dependence on the medicine, it can have hazardous effects down the line.

Tolerance is when a drug no longer works as well as it did before, forcing you to take more and more. Tolerance and dependence go hand in hand; dependence means you suffer negative effects when you stop taking the drug, also known as withdrawal symptoms. A large study on patients with depression showed no potential for tolerance, dependence, or abuse.

No study has shown any negative effects on patients’ health, outside of the normal side effects.

Positive long-term effects

If there aren’t any negative long-term effects from modafinil use, could there be good ones? Aside from the obvious benefit of improving a person’s condition, there could actually be some very uplifting benefits of modafinil in the long term.


Experts in psychology say it takes around 6 weeks to form a new habit. It’s possible to train yourself on modafinil to be more productive, and forge a habit that will stick with you even without the pill. Since modafinil helps you focus and get more done, you could have a long-term improvement in your work ethic if you use it diligently.


Life can get out of hand for all of us sometimes. Maybe you have too many things to do at once, or your work has many steps that create confusing situations. Whatever the case, you can become more organized by sticking to a modafinil schedule.

Make lists for the things you need to do, break down your activities into steps, and use modafinil’s ability to improve your executive cognition. Once you know how your brain works on modafinil, you could consciously do the same thing later.

Potential long-term problems

On the other hand, we could project some possible problems with modafinil when used for a long period of time.


You might feel like you can take on the world and do anything with modafinil, but be careful not to devote your entire life to work. If you take on more than you can handle, your stress levels can rise. Stress is detrimental to your health, it can even shave years off of your life.

The key, as with everything, is balance. You absolutely can improve yourself and your behavior with modafinil, but be mindful of your work-life balance. Take a day off from time to time and relax. You’ve earned it with all that work you’ve done!

What is Adrafinil?

We also have a brand new nootropics store, get all your cognitive enhancement needs! Check out our Nootropics Store

What exactly is Adrafinil?

Adrafinil is a eurogenic stimulant on par with Modafinil, and is Provigil’s pro-drug, meaning it has the exact same effects as Modafinil, only once it has passed through the liver. The only reason it’s a different drug at all (the effects are exactly the same) is because the molecule is slightly changed, allowing it to mold into Modafinil in the liver, rather than immediately in the stomach (and thus is much cheaper to produce…..and even cheaper to purchase online!) It’s effects include increased memory and focus, euphoria, and unprecedented overall mental energy. Typical dosages range from 3-600milligrams (equivalent to 1-200mg of Modafinil.)

How does it compare to Modafinil?

Modafinilimage7In comparison to Modafinil, it is virtually identical in effects on a 1-3 per milligram basis. (1mg of Modafinil=3mg of Adrafinil) so dose accordingly. On our website, Adrafinil is 300mg per capsule, and sells for just under a dollar a capsule. Also going by the name “Olmifon” (though the use of that slang term is very uncommon;) many scientists see huge potential in Adrafinil powder for continued experimentation and improvement of the drug. Many have even praised Adrafinil as the research drug that helped us to bring about an even stronger Modafinil, “Armodafinil” and is confirmed as the way we learned how to metabolize eurogenic drugs, within the human liver.


A source of Modafinil and an extremely potent alertness aid, Adrafinil has been around since the 1960’s, and has been used in clinical settings as a wakefulness agent to combat narcolepsy, as well as for stopping obesity and ADHD. Interestingly enough, unlike many conventional stimulants, users report being able to sleep perfectly when using Modafinil and Adrafinil, and in my own personal experience, one can wake up the next morning after a full 6 hours of sleep, on either of these eurogenics, still feeling some of the drugs productivity effects! Adrafinil and Modafinil are truly unique and amazing drugs, and no conventional stimulants even come close to matching their effects in potency or lack of side effects.


AdrafinilAdrafinil costs exactly $1 per pill (slightly cheaper than the Modafinil we have) and while it is less potent on a per milligram basis, some people prefer 600mg of Adrafinil (2 Adrafinil caps) in comparison to 200mg of Modafinil-myself included. Adrafinil, in a way that is extremely potent, produces a feeling of both mental and physical energy, the main reason for its alleviation of fatigue and increase in confidence and energy.

Side Effects

This drug is considered extremely safe for use. However, several drawbacks, side effects in both the long and short term, are something every user of Adrafinil should be aware of.

Short term side effects

  • Increased thirst
  • Possible Insomnia
  • Headache if not enough water is consumed (interestingly enough, if you take choline with Adrafinil, it can actually help stop the headache…even though it doesn’t stimulate the acetylcholine receptors. )

Long Term Side Effects

If taken for long periods of time without a break (at least one day per week) fatigue can often times set in, both mentally and physically. Don’t take more than a week in a row without ensuring a tolerance break!

Final Thoughts

Adrafinil and Modafinil are two of the most potent drugs for cognitive enhancement, and share very similar prices and cognitive improvement effects. These are the pinnacle of cognitive enchancement, and I highly recommend both of them:)

Modafinil vs. the Racetams

Modafinil vs. Racetams

 Get Modafinil online right here!

Finding the real or correct medication that sparks the brain to perform is a rarity. It is like searching for the Holy Grail. However, there are a group of smart drugs also called nootropics that are being used to test the brain’s ability to work. There is Modafinil and then there are a couple of them from the Racetam family that is being slotted as the best by the users. But which is the best? Or is it a combination that works?  How do the basic cognitive faculties that we are born with can be enhanced artificially? Right now, the fight is between Modafinil Vs Racetams. Which stimulation works?

What methods work the best as brain boosters?


From time to time, people have resorted to various methods lie brain training via puzzles, dietary supplements, nutrients, herbs, even giving electric jolts and now come neuro-enhancements. It is like opening a new era in brain performing technology. Can these artificial methods to become intelligent really work? But what may work are the some Modafinilimage6smart drugs that can let the brain think ten times its normal capacity. They will not change the basic DNA of the organ nor will they make a person super human. However, for sometime they will bring a sense of neuro-elasticity to the region and activate some chemicals.


The medical community started to work on how to curtail drowsiness or excessive sleepiness in individuals that was impairing the brain from working.  Even age-related brain fog, degenerative issues, OSA and ADHD in children made them think of deriving some formulations for such patients. As the formulations started to help them, its major successes were seen in how the cognitive abilities improved. This was the impetus for even normal people who were being depraved and brain fogged to try them out. As lifestyles have changed so have the needs to cope with it. Keeping an agile mind is important.


Modafinil Vs Racetams


What works for Modafinil?


It has been the first nootropic to make it to the smart drug club. Some users claim to work non-stop without any fatigue for 48 hours. It was used mainly to treat narcolepsy and OSA. People with shift sleep disorder also are prescribed with this medication. It can be purchased without a prescription as well. It is a mild stimulant.


What works for Racetams?


Racetams have the same chemical structure but may vary with some additional molecule. In the USA, they are not regulated. Hence they are sold as dietary supplements online. Each comes with a different ability to cross the blood-brain barrier. The more fat soluble they are, the easier it is for them to affect the brain’s performance.


The main ones sold on the market are:

  • Piracetam
  • Aniracetam
  • Oxiracetam
  • Pramiracetam


Piracetam is one of the first smart drugs that can disable the enzyme of a neurotransmitter called acetylcholine. It is water soluble, unlike Pramiracetam and Oxiracetam, which are fat-soluble. These are also known as cognitive enhancers.


Between the Racetams and Modafinil the latter is milder.

Provigil vs. Modafinil vs. Armodafinil

Provigil, Buy Modafinil, Armodafinil? How do these compare


It would not be wrong to say that if a person is of mediocre intelligence, then there is no way his brain can be ‘upgraded’. However, what can be done is to introduce the brain to some remedy that will energize it and make it work much better. There are many kinds of natural, synthetic and chemical brain boosters that have hit the market. Among the most noticeable that can be said to improve the functioning of the grey matter include well-known names like Provigil, Modafinil and Armodafinil. How do these compare with each other to help a user? It would be best to understand each one’s formulation before taking a decision as to which one is apt.


How do you sharpen your wits?


To look smart often people choose clothes from the best brands. Athletes choose various kinds of supplements to ensure they are physically fit and perform well. In the same manner, some people need a boost for the grey matter. To sharpen your wits you need to be alert and vigilant. The sharpness will manifest when proper boosters are taken. There Modafinilimage7are a variety of boosters that work on different areas of the brain. It allows the person to be focused, have memory recall and also be in a good mood. Nutrients, herbs and chemical formulations are known to give the best results. Today the biggest demand from the market is for brain boosters like Provigil, Modafinil and Armodafinil. However, people wish to know how each one compares over the other.



Provigil Modafinil Armodafinil
Brand name for Modafinil Helps in regulating sleep Energizes the mind with small doses
Works just like generic modafinil Mild stimulant No nervousness
Used by people to remain alert and vigilant Less usage recommended No high or low BP
Needs a doctor’s recommendation No prescription required Prescription needed
Works for narcolepsy, OSA Can be used by normal people On withdrawal it does not impact the serious patient
Impact for 10 hours Impact for 5-10 hours Remain awake for longer time


The main difference between Modafinil and Armodafinil is in its molecular structure. The latter is an enantiomer of generic modafinil. It is a purer version of the original structure. Since Armodafinil is pure, a lesser dose is sufficient to help the user. Provigil is the brand that contains the modafinil structure. A French company originally made it but now Cephalon of USA manufactures this drug. However, the potency of the drugs differs from one user to another. One person may have a side effect, but the other may not have that but another adverse reaction. So one will eventually have to go by personal experience to understand which drug works better.


All smart drugs process information faster


With the nature of the molecular structure, most of the smart drugs are able to help the user to sift information easily. They are able to enhance the thinking pattern and focus is very proper. Mental activity can be heightened in these ways.

Modafinil vs. Sunifiram

The latest addition to the world of smart drugs: Modafinil and Sunifiram 

Buy modafinil online right here!

The recently developed smart drug, Sunifiram has shown a great amount of potentiality in its initial testing. Known to affect AMPA glutamate effect in the brain, Sunifiram is classed as Ampakine. Sunifiram reviews suggest that its benefit is somewhat similar to that of Piracetum, which is another smart drug. It has a greater degree of potency when pitted against Piracetum. Like Modafinil, Sunifiram’s advantage lies in the fact that it is leads to cognitive enhancement that encompasses the improvement in recall and memory consolidation, improvement in  attention span, learning, enhancement in alertness and decision making potentiality. The latest nootropic drug has been under researches since the year 2000. Although, the drug has same chemical structure as that of Modafinil, it is said to be far more potential than Modafinil. Initial studies about the drug Sunifiram has Modafinilimage12shown only positive results for it is a great memory enhancer just like Modafinil and can very smartly deal with the cognitive decline which is normally noticed in patients suffering from Alzheimer’s disease.

Modafinil Vs Sunifiram: Which is better?

Sunifiram reviews depict that it performs much better than Modafinil when it comes to memory enhancement. Having the similar mode of action just like other racetams, it stimulates same receptors groups. The primary mechanism of Sunifiram is that of ampakine that stimulates AMPA receptors responsible for the production of glutamate in the brain. During the tests conducted upon Sunifiram, it was observed by the researchers that after the intake, there was an increase glutamate production and AMPA activity. Glutamate is the most significant neurotransmitter that enhances cognitive functioning and transmits excitatory signals in order to form synaptic connections in between the neurons to aid survival of brain cells. However, Modafinil, the psychostimulant is more widely prescribed than Sunifiram for it treats hyperactivity of mental imbalances, namely, ADHD. Best part of taking Modafinil is that it has no side effects unlike Sunifiram, which is reported of side effects such as nausea, increased heart beat rate, feeling of nervousness. Both the nootropic drugs, Sunifiram and Modafinil dictate the brain mechanism and also the synaptic plasticity. Deficiency in the level of Glutamate can cause cognitive impairment, and hence both the nootropics are widely taken by students, business executives, scientists, athletes. Scientific studies determine that the operational mechanics of Sunifiram promote anti-amnesiac properties. Now, this is directly associated with enhancement of brain functionality, which relates to attention, memory and cognition. However, Modafinil is more concerned with secretion of brain hormones such as dopamine, histamine that acts as a tool for enhancing cognitive productivity. When you talk of side effects, Modafinil is better for it causes no side effect.

Sunifiram modulating the production of acetylcholine like Modafinil

As per the ephemeral evidence the drug, Sunifiram has properties that stimulate the release of cholinergic properties in the cerebral cortex. An enhanced level of acetylcholine is linked with the enhancement of perception, focus and reasoning power. Sunifiram can treat several mental afflictions and is legal in major parts of the world unlike Modafinil.

Modafinil vs. Ritalin

Modafinil VS Ritalin

The latest battle which is taking place around the web on user board of discussion is whether Modafinil is better or Ritalin. Both the smart drugs have the potential to promote wakefulness. Ritalin, the well-known smart drug, is a psychostimulant, which is widely prescribed for it treats effectively hyperactive mental imbalance associated with ADHD. In the recent years, Modafinil has moved ahead of almost every smart drug owing to the cutting-edge efficacy. The drug claims to offer users with wildly improved cognitive control and ability. In this respect, there are negative feedbacks coming up for Ritalin for those who are prescribed with Ritalin suffer from unwanted side effects. However, individuals have reaped the mental benefits through its blunt qualities.

The prescription medicine: Ritalin

Methylphenidate or Ritalin is strictly a prescription drug that is controlled by Schedule II of FDA. The drug is intended for addressing symptoms of ADHD and can effectively quell hyperactive mind and the short span of gaining attention connected to mental disorder. People who have trouble staying awake or the ones having narcoleptic disorders can address the mental imbalances with Modafinil and Ritalin. When compared to Modafinil, Ritalin attains the effect of wakefulness by helping the great uptake of norepinephrine and dopamine. Such great hormones are really powerful neurotransmitters that may create superb spikes of wakefulness and energy to pacify negative or erratic emotions. Retalin users due to the chemical reactions may suffer from dependency whereby on quitting the Modafinilimage13nootropic there can be a sort of withdrawal symptom. Majority of the children who consumed Ritalin are diagnosed with ADHD. However, Modafinil attains its effect through the release of natural chemicals and histamine chemical that gets triggered through an immune response. Histamines are actually part of the sleep regulation system of the brain that in turn generates alertness and incredible concentration that are associated with Modafinil.

Modafinil VS Ritalin: Their pricing and legality

Well, if you talk about the efficacy, then certainly Modafinil has an edge over other notropics. However, if one considers the pricing, then Ritalin is far cheaper than Modafinil. A 30-day supply of Modafinil might cost you $1000, which is totally unacceptable by the masses. Without the help of medical insurance, no one can afford Modafinil’s expense. Only those who suffer from severest sleep disorders must go for Modafinil. Surprisingly, 30-60 days of Ritalin costs only $85, which is much lesser and cost-effective than Modafinil. Apart from this, usage of Ritalin can be covered by insurance also. If you are in the US, then certainly you need prescriptions to buy both the legal nootropics. For those, looking forward to possessing Modafinil without prescription may purchase it from overseas pharmacies. Users can also purchase the precursor to Modafinil that can be bought easily. If you crave for sharp concentration and intense thoughts, then you can buy the nootropics after giving a thought to the pricing. For hassle-free purchase of cognitive enhancing nootropic drugs, go for only bulk purchase of nootropics from reliable online stores.



Provigil vs. Modafinil

Are Provigil and Modafinil the same?


Are Provigil and Modafinil the same? In order to answer this question, there are certain things, which need to be taken into consideration. Let us first find out what actually Provigil and Modafinil are, only then we will be able to come to a conclusion with regards to their similarities.


At the very beginning it must be mentioned that Modafinil is an energizer drug which has numerous effects on our body and mind. It is also used to improve wakefulness. When it comes to Provigil, this too is used to enhance the wakefulness in an individual and at the same time helps to rejuvenate our mind.

Ingredients of Provigil

Modafinilimage21Before we know how exactly Provigil works, let’s have a look at the ingredients first. Here is a list of ingredients present in Provigil


  1. Lactose monohydrate,
  2. Microcrystalline cellulose,
  3. Pregelatinized starch,
  4. Croscarmellose sodium,
  5. Povidone,
  6. Magnesium stearate.


Ingredients of Modafinil


Here is a list of ingredients present in Modafinil

  1. Lactose monohydrate,
  2. Microcrystalline cellulose,
  3. Pregelatinized starch,
  4. Croscarmellose sodium,
  5. Povidone,
  6. Magnesium stearate.


If you have a look at the list of the ingredients, you would find that they are similar, so it can be safely concluded that  their ingredients being similar, they would have the similar effects on our body.

Their effects

Let’s have a look at some of the common effects these two drugs have

Positive effects

  1. Improved Metabolism: Both these drugs are capable of improving our metabolism to a great extent. They affect the digestive system and the digestive process of our body. This increases the level of metabolism which in turn keeps our entire physiological structure in shape.
  2. Enhanced Concentration: Both these drugs have proven to be very helpful when it comes to improving the level of concentration. They affect that section of the brain which is responsible for concentrating. These drugs also affect our nervous system and keep us steady and awakened.
  3. Improved Mental State: The fact that these drugs help to get rid of dizziness and lethargy, these rejuvenate our mind and body, which results in an improved mental state. These drugs have proven to be very helpful to the students and those who are in the field of studies and research work. They are being prescribed to the students who have a lower level of concentration.
  4. Improved Appetite: The fact that these drugs improve the overall metabolism of our body, they also help in an improved appetite, which helps us to stay healthy.
  5. Weight Loss: It has been found that both these drugs are excellent weight loss supplements and if used properly, they can certainly yield very good results.

Negative Effects

If these drugs are used beyond the prescribed level, then both can yield certain common negative outcomes, which are as –

  1. Dizziness
  2. Digestion Problem
  3. Sweat
  4. Increased heart rate

Are Provigil and Modafinil the same? I hope the fact that these two drugs have so many things in common proves that Provigil and Modafinil are indeed the same.



Is Modafinil the Strongest Nootropic

Is Modafinil the strongest nootropic?

It may not be wrong to assume that a lot of people have been able to find a solution to the energy related problems with regard to their performance simply because they have been able to find some amount of respect in using modafinil.  But what happens to the people who are suffering from acute energy crisis?  What about people who are in need of an extremely strong nootropic that is going to be able to take care of their lethargic needs?  It is in this regard that a question is asked very often: is modafinil the strongest nootropic?

When it comes to answering this question, there are a number of factors that have to be taken into account; ranging from the opinion of medical practitioners who have put in years of survey in order to understand modafinil better, to the views of mundane ordinary people who have found respite in the usage of this product.  In order to determine whether modafinil is the strongest nootropic or not, here are a few parameters that are central to determining whether modafinil is by far the most effective performance enhancing tool that is available to people.Modafinilimage23


It is seen that the majority of drugs that people consume throughout their lives is seen to be vastly ineffective as time passes by simply because the body develops a sort of immunity towards it.  This is not perceived as a negative factor but something that is the same for all sorts of drugs that have a lifecycle and must see a natural progressive ending.

With regard to understanding modafinil, the inputs that have been provided by patients throughout the years is that it maintains the same level of accuracy and precision with regard to taking care of energy related problems and hardly ever fails anyone.  Only instances where there have been possibilities of a solution not been provided is when the basic core of the problem that is faced by a person is with regard to some deep-rooted deficiency or disease.

Medicinal opinion
It may not be wrong to state that the opinion of medical practitioners is final with regard to determining the feasibility of drugs.  In this regard, it may be noteworthy to mention that medical practitioners all over the world have been able to subscribe to the fact that modafinil is by far the strongest nootropic that is available to people on the market.  They are able to provide this sort of opinion simply because they have their medical experience and patients’ opinions to their credit.

In order to sum it up, it would be right to attribute modafinil as of the strongest nootropic for another reason being that most of the other nootropics that are available on the market are simply derivatives of this one.  That by itself implies that modafinil is far superior to others with regard to the strength that it has to offer with regard to medicinal properties.  It can be relied upon easily.

Modafinil. vs. Adderall

Modafinil vs. Adderall

When it comes to consuming performance enhancing agents, the ideal thing that is to be done is taking the help of a professional doctor who has a clear idea of the various technicalities.  He will be the person to guide a patient best.  However, there are some people who are always determined in order to be able to take matters into their own hands.

The paradox
A normal human being is always going to be incapable of making technical decisions that a trained personnel with regard to the world of medicines.  The latter has educational qualifications as well as practical training in order to get a better understanding of things.  In this regard, it is his advice, which is the best.  However, there are certain situations that are to be taken into account where the decision has to be taken by the consumer himself and that is going to require a bit of knowledge, however, mediocre that may be in terms of professional appreciation.Modafinilimage24

The diseases

When it comes to deciding between modafinil vs adderall, there is a glaring difference that has to be taken into account when making the decision.  What is required here is a clear understanding about the disease and the symptoms, and the required medicines that are necessary to be able to treat them.

In order to enumerate the problems that are associated with the former, generally laziness and lack of energy is what determines the use of modafinil.  Simply, it is a performance enhancing agent that is capable of augmenting the energy needs of the person in question.

With regard to the latter, that is adderall, the explanation is not so simple.  The situations where these are used is actually different.  It is given to people who have a slight brain disorder that makes them incapable of being able to control their sleep cycles and daily activities.

If it is looked at from a completely medicinal aspect, it may not be wrong to assume that the latter is actually a more critical form of administering a drug or agent.  Therefore, when it comes to deciding between these two medicinal aspects, it is always advised to have a clear idea with regard to the needs that are to be met first.


In fact, for making a decision between these two performance enhancing agents, a clear demarcation comes to mind because  it is very difficult to get a hold of the latter medicine without having a proper prescription from a qualified professional.  The former, however, can be purchased from a chemist, and does not require that cumbersome a process as that of adderall.

Final call
While it may be absolutely enlightening to access an abundance of information on the Internet and feel the need to take a decision for yourself, it is best advised to leave such critical choices to the doctors.  Not only does it determine the choice you’re making with regard to the medicine; it also pinpoints the health impairments that are being addressed during the process.