Pre-Med student experience with Modafinil

Please note that I’ve found modafinil to be an incredibly positive change in my life In this regard, I may be overly biased in favour of modafinil.

premedI started taking modafinil on and off starting in my 4th year of university. I’ve lost my girlfriend to cancer, my grades were plummeting and my depression hit a point where I wasn’t even going to many of my classes. As a pre-med student, I was about to throw away my dreams. I always hated going to the doctor, so I did my own research (pharmacy specialization by the way) and found the miracle drug ‘modafinil’.
Before I talk about the effects on me, please note I weigh 190lb, athletic, 6’0. I took 200g on the days I needed a boost, 100mg after waking and 100mg in the afternoon with no other boosts such as coffee. I’ve ordered from modup and it took 1 weeks to get to Skypax, then 2 weeks to get to my country.

The very first benefits I noticed were my energy and motivation levels as well as my productivity. All of a sudden, a swim after gym didn’t seem like a sweat. Getting my affairs sorted for med school next year was a priority. Stuff got done before I fucked around. Procrastination was kept to a minimum, time-wasting was eliminated. Nothing to do? I made something happen. I have been motivated as hell to get my life on track and beyond. All of a sudden, everything is a goal, not an obstacle. Confidence and self-esteem hit me out of the blue.

There were ups and downs, and still are, but for the most part, being confident, self-assured, and feeling like a high-self-esteem person has been my state on modafinil for a while now. I started having these uncanny conversational skills about a week into my modafinil use. All of a sudden, making jokes and puns was as natural as breathing. Eye-contact was solid, with men and women, especially women. People have commented on me being a good conversationalist. The withdrawals were mostly laziness and depression, (my usual states when I am not on modafinil, but amplified). I took moda 5 days in a row for a hard week, and the following weekend was spent mostly sleeping, eating or watching Netflix.

The biggest benefits for me were that social anxiety was gone. Whatever was on my mind, I would say it, and social vibes improve tremendously. For the studying, I was able to study more due to the euphoric effects, and more efficient because I was more motivated to learn. Note: When I took modafinil, I stopped drinking coffee, I don’t drink alcohol, take no SSRI/MAO-I’s, etc. The only other substances I took on top of modafinil were multi vitamins and omega 3’s, which are non-interactive neutraceuticals I’ve been taking my whole life.

Student usage of Modafinil in UK Universities

During the 2014 final exam period, we asked a sample of  UK customers to complete an anonymous survey, a strong correlation appeared between the top UK Universities and the percentage of Modafinil orders being placed by students from these Universities.

This is shown in the below pie chart:

UK modafinil

Cambridge and Oxford (the top two universities in the UK) students make up the largest portion of students using Modvigil from Modup.net in the UK.

Adrafinil Vs Modafinil vs Armodafinil

As the market for Modafinil has increased greatly over the last few years, drug makers are capitalizing on this by introducing new products to the market. These new products are marketed as successors to Modafinil, or as newer more superior versions of the popular pill. But how different are they in reality? In this article Adrafinil vs Modafinil vs Armodafinil we will examine the differences in the chemical structures of these products.

Adrafinil

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Adrafinil was actually created before Modafinil. In the 1970s it was designed by the French pharmaceutical company Group Lafon. Adrafinil is a prodrug of Modafinil. A prodrug is any drug that transforms into another when the body metabolizes it. Prodrugs are actually quite common. For instance, many formulations of cough syrup contain codeine, which is later converted into morphine inside the body. So codeine is a prodrug of morphine.

This means that Adrafinil is converted to Modafinil naturally inside the liver. As a result, the effects are identical; a dose of Adrafinil literally becomes a dose of Modafinil. However the additional processing that is required by the liver does have some consequences. There is stress on the liver during the conversion process as enzymes are consumed. These enzymes are replenished over time, but in some cases they are necessary for other conversions. This is why combining medicines can exacerbate side effects and symptoms. The first drug consumes the enzyme that the second drug needs, and so the second drug’s effects are modified.

Also due to the additional processing, Adrafinil takes longer to take effect than Modafinil.
Adrafinil was sold as Olmifon by Cephalon, the same company that sells Modafinil in its brand-name form. Cephalon discontinued sales of Adrafinil in 2011. It is currently still available in powder form from various Chinese suppliers. Some people have recommended buying Adrafinil this way because Adrafinil is unregulated in numerous countries and is therefore easier to import and possess. However these suppliers have unreliable quality control and pose a danger to the consumer’s health. In general, you should only purchase medicine from licensed pharmaceutical manufacturers.

Modafinil

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Modafinil is the most popular form of the drug available on the market today. It’s proven to be the most reliable, effective, and consistent way to improve your energy and focus for an entire day. The drug is marketed under a large number of brand names, most of which are generic. Modafinil is sold under the names Alertec, Alertex, BravaMax, Carim, Provake, Mentix, Modasomil, Modavigil,Modalert, Modapro, Modafil, Modvigil, Modatec, Modiodal, Provigil, Resotyl, Stavigile, Vigia, Vigicer, Vigil, and Zalux.

Modafinil is a racemic mixture. Racemic mixtures are also quite common in pharmaceuticals. So what are they, and why does it matter?

A large number of chemicals exist in two forms. These forms are called enantiomers. The two forms are chemically identical, and have the exact same structure. The only difference is that they are mirror images of each other. A good analogy can be found in your hands. You have two hands, which are identical and structurally the same, however they are mirror opposites. One is left, and one is right. Enantiomers are the “left and right” versions of a drug. These are labled as the S and R enantiomers.

Just as you have a dominant hand that is usually better at doing most tasks, there is also usually one enantiomer that is responsible for the majority of a drug’s effects. The other enantiomer can contribute to the effects, or in some cases may present adverse side effects. In rare cases, the wrong enantiomer can be extremely harmful. Sometimes one enantiomer is completely useless.

Most racemic mixtures are equally balanced, meaning that the amount of the “left” enantiomer is equal to the amount of the “right” one. Modafinil is an equal combination of its S- and R- enantiomers. This is important, because in Modafinil’s case both enantiomers have a psychoactive function. A study in 2003 revealed that the S- enantiomer is also responsible for effects, and also showed that it is removed from the body faster than the R- enantiomer. Neither one is more or less responsible for negative side effects. Just as you sometimes need two hands to do a job correctly, Modafinil uses both of its enantiomers to provide the ideal effect on your body and mind.

Armodafinil vs Modafinil

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Armodafinil has appeared on markets more recently under brand names such as Armod, Artvigil, Biryth, Nuvigil, Waklert. It’s been marketed as the successor to Modafinil, and is purportedly more effective at lower doses. Armodafinil was introduced in 2007 by Cephalon.

Armodafinil is an enantiopure drug. Enantiopure drugs are those that contain only one of the enantiomers available, R or S. What this means is that Modafinil already contains Armodafinil. Armodafinil is half of the racemic mixture in Modafinil.

As mentioned, the R enantiomer is longer acting and is the one most responsible for the effects of Modafinil. Since the S enantiomer is not as strong, Armodafinil’s dosage is therefore lower. Most doses are 150mg compared to Modafinil’s 200mg standard dose. The effects last about the same time, but Armodafinil takes longer to reach its peak than Modafinil does. This is because the S enantiomer peaks faster, and also leaves the body faster. Without this enantiomer Armodafinil users find that the effects take longer to kick in and are less noticeable at first. Reports of headaches were higher in patients taking Armodafinl, according to a 2009 study which compared Armodafinil to Modafinil. The potential benefit is that users will have more effects later in the day, perhaps when they need them more.

Armodafinil shows the exact same side effect profile as Modafinil. Why then was the S enantiomer removed? If it’s not doing any harm, and in fact contributes to the potent effect of Modafinil, why take it out?

The answer can be found by looking at the pharmaceutical industry itself. Drugs cost billions of dollars to produce. This is because numerous drugs that are researched and tested fail to become successful. One successful drug has to pay for 8-10 more that didn’t work. When a successful drug is found, a patent is filed and the company gets 20 years to produce the drug exclusively, ensuring a profit. As the patent expires, drug companies attempt to find ways to continue making money from their successful product.

Modafinil’s patent was set to expire around 2010. This would mean that Cephalon would no longer profit as much since generic formulations would quickly take over the market. In order to reduce the impact of Modafinil’s generic availability, they created a patent for its R- enantiomer as an emantiopure drug. Patent law allows for different formulations to be treated as completely separate drugs. This means that Armodafinil was created without spending money on additional research, essentially Cephalon got two drugs for the price of one. Armodafinil was released in 2007, and Cephalon began marketing it shortly after Modafinil’s patent officially expired.

This practice is hardly new. Companies have been doing this for decades. During the 20 years of exclusivity, they have built up a large base of loyal consumers who are pleased with their product, in this case Modafinil. By anticipating the expiration date, they can contact Modafinil users and their doctors, and encourage them to switch to the “new Modafinil.” They will often claim that it is better, “new and improved.” In addition, they will have had time to test the pill for new applications, allowing them to market it to more people. When users switch from Modafinil to Armodafinil, the pharmaceutical company continues to profit. Little do the customers know that they’ve already been taking the same drug, and could be saving hundreds of dollars by taking a generic.

Don’t be fooled by corporate tactics. At the end of the day, Armodafinil is only half of what Modafinil is. Nothing beats the original formulation that we’ve come to know and love.

Modvigil vs Modalert

Modafinil has been available in generic form since 2010 and you can buy modafinil online. In the last few years dozens of companies have stepped up to produce their own generic version of Modafinil. You might be confused when you see the laundry list of names that are out there: Alertec, Alertex, BravaMax, Carim, Provake, Mentix, Modasomil, Modavigil, Modalert, Modapro, Modafil, Modvigil, Modatec, Modiodal, Provigil, Resotyl, Stavigile, Vigia, Vigicer, Vigil, and Zalux. Don’t be, they are in fact one and the same.

Modvigil vs Modalert

Once a patent for a drug expires any pharmaceutical manufacturer can produce it. Modafinil had become quite popular, and so many companies all over the world sought to produce their own version of generic Modafinil. Many of the above names are catered to a local market or language to improve sales. Regardless of what name they have, they are essentially the same exact thing.

Generic medicines are made by following the recipe outlined in the original patent. Think of it like baking a cake. The original brand-name manufacturer made the first cake, and patented its ingredients and methods. Now that information is available to the public, and anyone can make the same cake. The FDA regulates the generic medicine (or cake) market to ensure that the product you receive matches the original brand-name product. If the brand-name product created a “Chocolate Raspberry Layer Cake” then the generic version must also be the same exact flavor.

What makes generics different is that they are able to use different quality ingredients, or in some cases different quantities of those ingredients to make their cake. Perhaps one manufacturer uses 100% dark chocolate from Brazil, while another uses a cheaper 90% semi-sweet chocolate from Asia. One factory uses premium flour and sugar while another decides to use an artificial sweetener. The cakes will have the same basic flavor, but they won’t be exactly the same. Some might be a little better than others.

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Generics can also use different packaging. One company simply wraps his cake in clear plastic to save some money, while another puts it in an elegant box. The packaging doesn’t affect the taste, just the presentation.
Ultimately this explains the differences in price between generic medicines. The only difference between generic medicines is the ingredients used to make them and the way they are packaged. Generics are always cheaper than brand-name drugs because the generic maker didn’t have to invest in research, testing, or marketing.

But are generics really effective? The FDA requires that all generic medicines contain 85-128% of the brand name’s active ingredient. This means that generics may sometimes be a bit weaker than the original formula, or they could even be a bit stronger. But in general they must fall within that range. All generics, regardless of their brand, contain the same primary ingredient and roughly the same amount.

So why do some people boldly claim that one generic is more effective than other, while other people declare the exact opposite? Based on what has just been said, it’s completely possible that some generics contain more of the active ingredient than others. However if that were the case, there wouldn’t be a debate. People should unanimously agree that one generic is superior.

One of the reasons why users frequently disagree about which generic is better is due to the “Brand Name Placebo Effect.”

Modalert vs Modvigil

This effect occurs when people believe that the drug they have taken is working better due to its name, cost, or packaging. Names matter. There’s a reason why companies spend millions on marketing trying to come up with the best way to sell their product. Have you ever seen an energy drink named “Sleepy Time”? The price matters too. When we pay more for something, we want to justify that increase in price. A pill that costs $4 MUST work better than one which costs $1, right? When something is well packaged, we perceive it as better. Why else would high-end restaurants decorate their plates and spend so much time making them look appetizing? That sprig of parsley doesn’t make the food taste better, it only looks better.

What really matters is if the generic is tested and safe. One problem with generics is that many of the factories are located in different countries where testing standards and inspections are not as well enforced. The only generic to have been subjected to a battery of tests Modvigil, which is sold by Modup.net. Every batch is tested to ensure that it contains a high quantity of Modafinil, nothing more and nothing less. This guarantees your safety, which should be your primary concern any time you put something into your body. Modvigil’s packaging has also been praised as being high quality compared to other brands.